February 19, 2013: World’s renowned experts, eminent scientists and academics have contributed towards the latest series of the Lancet, Series 4 on Non-communicable Diseases (NCDs), launched on February 11, 2013. The Series builds on the High Level Meeting on NCDs convened by the United Nations in 2011 and on its previous series in 2010, 2007 and 2005. The Series, coordinated by Robert Beaglehole, aims to bring more evidence in the public domain, as the post-2015 agenda planning is underway. It also proposes cost-effective interventions to accelerate progress to avert millions of deaths, worldwide, by 2025. In this Series, our president, Dr. Sania Nishtar co-authored a viewpoint, ‘Improving responsiveness of health systems to non-communicable diseases with Prof. Rifat Atun of Imperial College, London as the lead author. This paper focuses on developing health systems in response to non-communicable diseases in the midst of challenges incurred by them.